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1.
Toxicol Ind Health ; : 7482337241247088, 2024 Apr 25.
Artículo en Inglés | MEDLINE | ID: mdl-38662893

RESUMEN

Exposure to heavy metals can result in various adverse health effects. Tehran is rated as one of the world's most polluted cities. Green space workers are continuously exposed to such pollutants in this city. Thus, this study aimed to estimate the health risks caused by exposure to heavy metals among green space workers. Eighty-eight workers and office personnel in two regions with different air quality levels were chosen for sampling. Air samples were collected using the NIOSH-7300 method and analyzed using an Inductively Coupled Plasma Optical Emission Spectrometry (ICP-OES) instrument. The hazard quotient (HQ) and the lifetime cancer risk (LTCR) were calculated to assess carcinogenic and non-carcinogenic risk levels. The results revealed that the rank order of heavy metals was determined as Zn, Pb, Mn, Ni, Co, and Cd. Workers were subjected to higher concentrations of Ni, Pb, Zn, and Co than office personnel. Furthermore, the Cd, Co, and Zn exposure levels stood significantly higher in region 6 than in region 14. Non-carcinogenic risk levels for all participants fell within the acceptable range. Moreover, no employee had a carcinogenic risk level within the acceptable range when exposed to Cd. Also, 2.3% of individuals demonstrated Ni's acceptable carcinogenic risk level. Owing unacceptable risk levels, proper interventions are required to minimize occupational exposure to heavy metals. These interventions include optimizing shift schedules, using personal protective equipment, and conducting regular health assessments.

2.
Vector Borne Zoonotic Dis ; 24(3): 159-165, 2024 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-38016137

RESUMEN

Background: Phlebotomus papatasi (Diptera: Psychodidae) is the main vector of zoonotic cutaneous leishmaniasis. Wolbachia is a symbiotic alphaproteobacteria of arthropods that can be involved in susceptibility or resistance. This study aimed to investigate the relationship between Wolbachia and Deltamethrin susceptibility/resistance in Ph. papatasi. Deltamethrin filter papers (0.00002%) were used to test sand fly field collected from southern Iran. After the test, PCR amplification of the Wolbachia surface protein gene (wsp) was used to measure Wolbachia infection rate in the killed, surviving, and control groups. Result: The rates of infection by Wolbachia strain (wPap, super group A) differed between killed (susceptible) and surviving (resistant) Ph. papatasi specimens. The rate of Wolbachia infection in susceptible individuals was more than twice (2.3) (39% vs. 17%) in resistant individuals with the same genetic background. This difference was highly significant (p < 0.001), indicating a positive association between Wolbachia infection and susceptibility to Deltamethrin. In addition, the results showed that Deltamethrin can act as a PCR inhibitor during detection of Wolbachia in Ph. papatasi. Conclusion: Results of this study show that Wolbachia is associated with Deltamethrin susceptibility level in Ph. papatasi. Also, as Deltamethrin has been identified as a PCR inhibitor, great care must be taken in interpreting Wolbachia infection status in infected populations. The results of this study may provide information for a better understanding of the host-symbiont relationship, as well as application of host symbiosis in pest management.


Asunto(s)
Insecticidas , Leishmaniasis Cutánea , Nitrilos , Phlebotomus , Psychodidae , Piretrinas , Wolbachia , Animales , Humanos , Phlebotomus/microbiología , Insecticidas/farmacología , Wolbachia/genética , Leishmaniasis Cutánea/veterinaria
3.
Sci Rep ; 13(1): 14912, 2023 09 09.
Artículo en Inglés | MEDLINE | ID: mdl-37689736

RESUMEN

Vector-borne diseases, among them leishmaniasis, cause more than 700,000 deaths annually. The lack of an effective vaccination and the increasing resistance of sand flies to insecticides require the urgent development of innovative approaches to contain the disease. The use of engineered bacteria that express anti-parasite molecules (paratransgenesis) shows much promise. However, a challenge for implementation of this strategy is to devise means to introduce modified bacteria into sand flies in the field. In this study, we use rodent food bait as a delivery strategy to introduce two mCherry-fluorescent bacteria, Serratia AS1 and Enterobacter cloacae, into adult sand flies in field settings. Bacteria-infected food was provided to Rhombomys opimus rodents. These bacteria transiently pass through the rodent alimentary tract and are delivered to larval habitats with the rodent feces. The feces are ingested by sand fly larvae and, in the case of Serratia AS1, are trans-stadially transmitted to adults. This is the first report of targeting delivery of Serratia AS1 in a paratransgenic system to control transmission of leishmaniasis under field condition. This novel strategy shows promise for delivering transgenic bacteria to Leishmania vectors in the field.

4.
Parasit Vectors ; 16(1): 284, 2023 Aug 14.
Artículo en Inglés | MEDLINE | ID: mdl-37580774

RESUMEN

BACKGROUND: The time required for PCR detection of DNA in human blood meals in vector mosquitoes may vary, depending on the molecular markers used, based on the size and copy number of the amplicons. Detailed knowledge of the blood-feeding behavior of mosquito populations in nature is an essential component for evaluating their vectorial capacity and for assessing the roles of individual vertebrates as potential hosts involved in the transmission of vector-borne diseases. METHODS: Laboratory experiments were conducted to compare the time course of PCR detection of DNA in human blood meals from individual blood-fed Anopheles stephensi mosquitoes, using loci with different characteristics, including two mitochondrial DNA (mtDNA) genes, cytB (228 bp) and 16S ribosomal RNA (rRNA) (157 bp) and nuclear Alu-repeat elements (226 bp) at different time points after the blood meal. RESULTS: Human DNA was detectable up to 84-120 h post-blood-feeding, depending on the length and copy number of the loci. Our results suggest that 16S rRNA and Alu-repeat markers can be successfully recovered from human DNA up to 5 days post-blood-meal. The 16S rDNA and Alu-repeat loci have a significantly (P = 0.008) slower decline rate than the cytB locus. Median detection periods (T50) for the amplicons were 117, 113 and 86.4 h for Alu-repeat, 16S rDNA and cytB, respectively, suggesting an inverse linear relationship between amplicon size/copy number and digestion time. CONCLUSION: This comparative study shows that the Alu-repeat locus is the most efficient marker for time-course identification of human DNA from blood meals in female mosquitoes. It is also a promising tool for determining the anthropophilic index (AI) or human blood index (HBI), i.e. the proportion of blood meals from humans, which is often reported as a relative measure of anthropophagy of different mosquito vectors, and hence a measure of the vector competence of mosquito species collected in the field.


Asunto(s)
Anopheles , Animales , Humanos , Femenino , Anopheles/genética , Genes Mitocondriales , ARN Ribosómico 16S/genética , Elementos Alu/genética , Mosquitos Vectores , ADN Mitocondrial/genética , ADN Ribosómico , Comidas , Conducta Alimentaria
5.
Ann Med Surg (Lond) ; 85(5): 1678-1684, 2023 May.
Artículo en Inglés | MEDLINE | ID: mdl-37229071

RESUMEN

Studies on coronavirus disease 2019 (COVID-19) symptoms, post-coronavirus disease (COVID) conditions, and vaccination outcomes in Pakistan are limited and inconsistent. The study investigated differences in symptoms and post-COVID conditions between vaccinated and unvaccinated individuals and the impact of vaccination on illness duration based on existing literature. Methods: The study was a 3-month cross-sectional study conducted in Peshawar, Pakistan. It targeted individuals aged 16 and above who had contracted COVID-19 at least once during the recent pandemic, regardless of gender, and confirmed through reverse transcriptase polymerase chain reaction testing. The sample size was 250, determined using the WHO sample size calculator. Data were collected through questionnaires after obtaining verbal consent and analyzed using IBM SPSS version 26, taking into account their vaccination status along with other important variables. Results: Among the 250 respondents, 143 (57.2%) were unvaccinated, while 107 (42.8%) were vaccinated at the time of contracting COVID-19. Unvaccinated subjects developed a greater variety of symptoms that lasted for longer durations (P<0.001) with symptoms like dyspnea [55 (38.5%, P=0.011)], anosmia [76 (53.1%, P=0.001)], and chest pain [24 (16.8%, P=0.029)] occurring at greater percentages. Sixty-one (42.7%) unvaccinated subjects reported post-COVID conditions as opposed to 29 (27.1%) among the vaccinated group [P=0.011; odds ratio (OR)=0.5; 95% CI=0.29-0.86]. Conclusion: The study found that COVID-19 vaccination can reduce the duration and frequency of symptoms, as well as post-COVID conditions. This is the first research of its kind conducted in Peshawar, Pakistan, and may serve as a foundation for future research in this demographic.

6.
Sleep Biol Rhythms ; 20(2): 275-285, 2022 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-38469258

RESUMEN

Driver's drowsiness is one of the high-risk road behaviors that quadruples the risk of road accidents. Measures to deal with drowsiness during driving include listening to music. The present study investigates the effect of two types of music, namely Iranian high-tempo pop and classical music, on mental and physiological drowsiness during driving. Twelve male students at Tehran University of Medical Sciences within the normal range of the Epworth Drowsiness Scale (ESS) participated in this study. Two types of music (classical and pop) were assessed on two separate days with an interval of one week. The mental aspect of drowsiness was evaluated using the Karolinska Sleepiness Scale (KSS), the physiological aspect by monitoring the EEG and heart rate, and the functional aspect through the mean and standard deviation of speed and the Standard Deviation of Lateral Position (SDLP) in a driving simulator. The results showed that the brain waves (four algorithms (1) (θ + α)/ß, (2) α/ß, (3) (θ + α)/(α + ß) and (4) θ/ß), the KSS score, SDLP and standard deviation of speed all decrease while the mean heart rate increases when listening to music during driving compared to driving without music. No significant difference was observed in the mean speed when exposed to music. Moreover, no difference was observed between the effect of the two music styles, i.e. Iranian classical and pop music. Listening to Iranian classical and pop music while driving improves the driver's performance and reduces drowsiness. The present study showed that higher tempo music during driving can reduce drowsiness and change physiological responses and driving performance.

7.
Iran J Public Health ; 50(8): 1668-1677, 2021 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-34917538

RESUMEN

BACKGROUND: Mosquito species are highly considering as disease transmission as well as nuisance insects. One of the principal strategy to protect human from the mosquito bites is repellent agents. This study aimed to assess repellency of two organic essential oils, Eucalyptus globulus and Syzygium aromaticum from bites of malaria vector, Anopheles stephensi. METHODS: The study was conducted in 2019-2020. The components of essential oils of E. globulus and S. aromaticum was determined using gas chromatography/mass spectrometry. The unfed female mosquitoes aged 2-5 d old were used in all experiments. In vivo Klun and Debboun module bioassays were utilized on human-volunteer skin. The essential oils at serial concentrations were used to find repellent efficacy against Anopheles landings and bites. To find the synergistic effect, four combinations of the essential oils were tested. RESULTS: The main composition of E. globulus essential oil was 1,8-Cineol (78.20%), whereas that of S. aromaticum essential oil was 2-methoxy-3-(2-propenyl) (77.04%). Based on minimum effective dose (≤1% biting), 10% (v/v) of E. globulus showed high landing repellency (77.78%), whereas minimum effective dose of S. aromaticum at concentration of 1% had high landing repellency (88.89%). Among four combinations, the ratio of 1:1 of E. globulus (10%):S. aromaticum (1%) showed the most landing repellency (94.44%). CONCLUSION: The combinations of two essential oils had the most potential repellency effect against landing of mosquitoes. As essential oils are eco-friendly with less irritation for human skin, E. globulus and S. aromaticum essential oils are recommended as effective and safe mosquito repellents.

9.
MethodsX ; 8: 101354, 2021.
Artículo en Inglés | MEDLINE | ID: mdl-34430255

RESUMEN

This paper aimed to fabricate UV protective nanofibers by the use of specific nanoparticles. The DMF/TiO2 (Titanium dioxide), DMF/MWCNT (Multi-Walled Carbon Nano Tubes), and DMF/MWCNT+TiO2 (MWCNT: TiO2 mass ratio= 1:1) solutions were transferred into a syringe with a stainless steel needle with gauge 21. The electrospinning process was performed for 3 h at the optimized conditions. The surface morphology of nanofibers was characterized by field emission scanning electron microscopy (FESEM). Fourier transform infrared spectroscopy (FTIR) was utilized to characterize functional groups of oxidized MWCNTs and investigate the successful load of nanoparticles at the fiber surface. The UV protection property of nanofibers was investigated by measuring UV rays' transmittance through the composite web. The data of Spectroscopy was used to compute the UV protection factor (UPF). (1) The effect of CNT,TiO2, and CNT+TiO2 nanoparticles on ultraviolet protection property was analyzed separately and simultaneously. (2) The different concentrations of nanoparticles, including 1,5,10, & 15 wt%, were used to fabricate UV protective nanocomposites. (3) The electrospinning condition was optimized as a 15 cm distance between the needle tip and collector, 20 KV voltage, 250 RPM drum rotation, and 1.2 ml/h feeding rate to access the best nanofibers.

10.
Sci Justice ; 61(3): 227-234, 2021 05.
Artículo en Inglés | MEDLINE | ID: mdl-33985671

RESUMEN

Entomological material may be used to estimate the time since death occurred (postmortem interval, PMI) in forensically obscure cases. The method that is commonly used to calculate minimum post-mortem interval (mPMI, i.e., the least amount of time since one can be confident death occurred) is based on the relationship between insect development and ambient temerature. Isomegalen and isomorphen diagrams are among methods allowing to calculate the age of necorphagous insects, yet thermal summation models provide the most precise and acurate estimations. The digrams are prepared based on the length or the developmental stages of the larvae as a function of time and mean ambient temperature. A knowledge of thermal requirements, in particular lower temperature threshold (Dz) at which development of a species terminates, is of essential importance to calculate ADD (Accumulated Degree Days). In this study different temperature regimes were used to construct the isomorphen diagram, examinate changes in larval body length at different ambient temperatures and to estimate the thermal requirements for developemnt of Chrysomya albiceps, the most common dipteran species reported on human and animal cadavers in Iran. Six development events including hatching, 1st ecdysis, 2nd ecdysis, wandering, pupariation and eclosion were studied under eleven constant temperature regims (17-37 0C). The development rate of Ch. albiceps increased as temperature increased. The larval length peaked at the end of third stage and then decreased at wandering stage. The maximum larval length occurred at 72 h post oviposition at either 31, 33, or 35 °C. At 17 °C, larvae did not hatch from eggs and at 37 °C wandering larvae did not proceed to pupariation, and thus larval development were analysed at the nine left over temperatures. The development stages required at least (Dz ± SE) 13.04 ± 0.37, 14.29 ± 0.45, 15.69 ± 0.56, 15.18 ± 0.56, 14.94 ± 0.48, and 11.23 ± 0.41 °C to reach one of the successive developmentl events, respectively. The estimated thermal summation constant (k) for those the six events were 10.43 ± 0.27, 19.31 ± 0.32, 27.87 ± 1.3, 55.94 ± 1.82, 66.69 ± 3.5, and 143.52 ± 5.61 ADD accordingly.


Asunto(s)
Dípteros , Animales , Calliphoridae , Entomología , Humanos , Larva , Temperatura
11.
Artículo en Inglés | MEDLINE | ID: mdl-33807782

RESUMEN

Previous studies have demonstrated that a positive ergonomics climate with an equal focus on improving operational performance and employee well-being is beneficial to both employee health and organizational performance. This study aimed to assess the ergonomics climate at two power plants and examine its association with self-reported pain, performance, and well-being. At two power plants in Iran, survey responses from 109 and 110 employees were obtained. The questionnaires contained data on ergonomics climate, organizational performance, employee health, and self-reported pain. Results showed that the mean ergonomics climate scores between the Besat and Rey power plants were significantly different (p < 0.001). The overall ergonomics climate score, and all subscales scores, were positively associated with organizational performance (p < 0.001). The overall ergonomics climate score, and some of its subscales, were significantly associated with employees' general health (p < 0.001). The ergonomics climate score was significantly higher in the group of employees who reported musculoskeletal pain than those who did not report musculoskeletal pain (p < 0.05). Investigation of ergonomics climate can provide organizations with a baseline for prioritizing their values and finding areas for improving organizational performance and employee health.


Asunto(s)
Ergonomía , Cultura Organizacional , Humanos , Irán/epidemiología , Dolor , Autoinforme
12.
Work ; 68(3): 711-719, 2021.
Artículo en Inglés | MEDLINE | ID: mdl-33612515

RESUMEN

BACKGROUND: The study aimed to assess the interactive effects of industrial noise type, level and frequency characteristics on hand motor skills using the Minnesota Manual Dexterity Test and the Hand Tool Dexterity Test. METHODS: A total of ten nonsmoking male volunteers with normal hearing and vision were selected for this study. The study followed a full 3×3×2 factorial design. Independent variables were noise type (steady, intermittent and fluctuating), noise level (75, 85 and 95 dBA) and frequency characteristics ("roar" <2000 Hz and "hiss" >2000 Hz). RESULTS: For Minnesota Manual Dexterity Test, the lowest speed is related to steady hiss noise at 75 dBA and the highest speed is related to fluctuating roar noise at 95 dBA. The speed is being significantly affected by the frequency characteristic (P = 0.041) and noise type (P = 0.025). The effect of hiss noise on speed is greater than roar noise (P = 0.038). There is a significant difference (P = 0.035) between continuous noise and fluctuating noise. For the Hand Tool Dexterity Test, the lowest speed is related to fluctuating hiss noise at 95 dBA and the highest speed is related to steady roar noise at 95 dBA. The speed is being significantly affected by the frequency characteristic (P = 0.002), noise type (P = 0.0001) and noise level (P = 0.005). The effect of hiss noise on response variable to be greater than roar noise (P = 0.008). There is a significant difference (P = 0.0001) between steady noise and the two other types of noise, and also there is a significant difference between 75 dBA and 85 dBA level (P = 0.003). CONCLUSIONS: The results showed that on hand motor skills, speed response was influenced by three characteristics: the type of noise, frequency characteristics and noise level. Also, the effect of the hiss noise was more than the roar noise.


Asunto(s)
Mano , Destreza Motora , Humanos , Industrias , Masculino , Minnesota , Ruido/efectos adversos
13.
Int J Occup Saf Ergon ; 27(3): 654-663, 2021 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-31538862

RESUMEN

Purpose. The probability of being injured or killed from an occupational incident is much higher than a process mishap in the oil and gas industry. The aim of this study was to establish a model for predicting the probability of occupational fall incidents using Bayesian networks. Methods. The study was performed in a selected number of oil refineries. Bayesian network variables (n = 18) were identified using literature as well as expert knowledge. These contributing factors were categorized into four layers (organizational, supervisory, preconditions and unsafe acts) according to the Swiss cheese model. Causal relationships among contributing factors were determined using expert judgment in combination with Dempster-Shafer theory. The conditional probability table of each contributing factor was measured using a questionnaire. Results. The prior probability of fall events was 5.34% (53 cases per 1000 operational workers in 12 months). The posterior probability predicted that using fall protection devices and safe working platforms will decrease more than half (58%) of fall occupational incidents. Conclusion. Bayesian network features including graphical representation, easy belief updating, performance testing and sensitivity analysis facilitate the process of predicting occupational incident probability including fall events. The proposed approach is a step toward quantitative risk analysis of occupational incidents.


Asunto(s)
Industrias , Teorema de Bayes , Humanos , Probabilidad , Medición de Riesgo , Encuestas y Cuestionarios
14.
J Cardiovasc Thorac Res ; 12(1): 27-34, 2020.
Artículo en Inglés | MEDLINE | ID: mdl-32211135

RESUMEN

Introduction: Limited data are available on the association of Dietary Inflammatory Index (DII) with metabolic syndrome (MetS) and its components. The present study was conducted to investigate the association of DII with MetS and its components among Iranian adults. Methods: A total of 404 subjects, aged 18 years or older, were included in the current cross-sectional study. We used a validated and reliable 147-item food frequency questionnaire (FFQ) to assess dietary intakes. Fasting blood sample was obtained to quantify glycemic indicators and lipid profile. MetS was defined based on the guidelines of the National Cholesterol Education Program Adult Treatment Panel III (ATP III). Results: Mean age of study participants was 38.20 ± 9.55 years. No significant association was found between DII and odds of MetS (odds ratio [OR]: 0.92, 95% CI: 0.48-1.76). In terms of MetS components, a significant positive association was seen between DII scores and reduced levels of high-density lipoprotein cholesterol (HDL-C) (OR: 2.29, 95% CI: 1.32-3.97); such that after controlling for energy intake, demographic variables and BMI, participants in the highest category of DII had 2.71 times greater odds for having reduced levels of HDL-C (OR: 2.71, 95% CIs: 1.34, 5.47). There was no other significant association between other components of MetS and DII scores either before or after adjusting for confounding variables. Conclusion: We observed no significant association between DII and odds of MetS. However, higher score of DII was associated with lower levels of HDL.

15.
Med J Islam Repub Iran ; 33: 93, 2019.
Artículo en Inglés | MEDLINE | ID: mdl-31696087

RESUMEN

Background: There are many factors related to etiology of metabolic syndrome (MetS) including obesity. Spexin, a peptide hormone released from adipose tissue, is the most down-regulated gene in obese, compared to non-obese adipose tissue. Hence, it potentially contributes to the progression and development of metabolic diseases. This study was designed to evaluate serum concentration of spexin in patients with MetS compared to weight-matched and normal-weight controls. Methods: In this case-control study, 153 participants (51 per group) were collected from October 2014 to June 2016. The study groups were all matched for age and sex and included overweight/obese individuals with MetS and 2 control groups without MetS (including weight-matched and normal-weight participants). Body composition and serum concentration of spexin and leptin were measured. Results: Serum leptin and spexin levels were significantly higher and lower, respectively, in normal-weight compared to overweight/obese groups with/without MetS (p< 0.02). No significant difference was observed in serum leptin and spexin concentrations between the overweight/obese groups with/without MetS (p≥ 0.05). Also, spexin, with cutoff value of 4.6, had 78% sensitivity and 82% specificity for diagnosing overweight/obese from normal-weight participants. Spexin had 78% sensitivity and specificity, with cutoff value of 4.35, in diagnosing MetS participants from normal-weight group. Conclusion: This study found no correlation between the circulating level of spexin and MetS development. Higher serum concentration of spexin in normal-weight adults compared to the obese participants illustrated the potential role of this novel peptide in obesity.

16.
Obes Surg ; 29(10): 3125-3132, 2019 10.
Artículo en Inglés | MEDLINE | ID: mdl-31165402

RESUMEN

PURPOSE: Laparoscopic Roux-en-Y gastric bypass (LRYGB) and laparoscopic sleeve gastrectomy (LSG) are the most common techniques for treatment of morbid obesity. However, a few studies have compared the energy expenditure and plasma amino acid profile after LRYGB and LSG. The present study was conducted to assess the resting metabolic rate (RMR) and plasma amino acid profile in obese patients who underwent LRYGB and LSG before and 6 months after the surgery in order to compare these changes from baseline between the two procedures. MATERIALS AND METHODS: Forty-three adult obese patients participated in this study (LRYGB = 22 and LSG = 21) and were followed up for 6 months. RMR was measured by indirect calorimetry. The plasma amino acid profile was determined using high-performance liquid chromatography (HPLC). RESULTS: Mean percent excess weight loss (%WL) were 22.8 ± 4.5% and 23.3 ± 5.7% in LRYGB and LSG, respectively. RMR reduced significantly from baseline by - 459 ± 202 kcal/day in LRYGB and - 500 ± 262 kcal/day in LSG. RMR reduced beyond the expected decrease in both procedures. A decreasing trend was observed in the plasma concentration of branched-chain amino acids (BCAA), aromatic amino acids (AAA), and amino acid index (AAI) in both techniques. There was no significant difference in weight, RMR analysis, and amino acid change from baseline between LRYGB and LSG. CONCLUSION: Our results showed that the effects of LRYGB and LSG on RMR and amino acid profile were comparable.


Asunto(s)
Aminoácidos/sangre , Metabolismo Basal , Gastrectomía , Derivación Gástrica , Adulto , Femenino , Estudios de Seguimiento , Humanos , Laparoscopía , Masculino
17.
Clin Nutr ; 38(2): 522-528, 2019 04.
Artículo en Inglés | MEDLINE | ID: mdl-29731182

RESUMEN

BACKGROUND: Disturbance in the equilibrium of the gut microbiota has been involved in the pathophysiology of depression. Probiotics have the potential to healthfully modulate the gut microbiome. Prebiotics could also be effective by stimulation of growth of some bacterial species in the gut microbiota. OBJECTIVE: The aim of this double blind clinical trial, was to compare the effect of supplementation with the probiotic and prebiotic on the Beck Depression Inventory (BDI) score as a primary outcome as well as the kynurenine/tryptophan ratio and tryptophan/branch chain amino acids (BCAAs) ratio as secondary outcomes in patients with major depressive disorder (MDD). DESIGN: One hundred and ten depressed patients were randomly assigned to receive the probiotic (Lactobacillus helveticus and Bifidobacterium longum), prebiotic (galactooligosaccharide) or placebo for 8 weeks. Serum tryptophan and BCAAs were measured by HPLC, and kynurenine by ELISA kit. Dietary intake and physical activity of the participants were recorded at baseline. RESULTS: A total of 81 subjects (aged 36.5 ± 8.03 y; mean (95% CI), 2.27 (1.76-2.93) y of depression duration) completed the trial (28 in the probiotic group, 27 in the prebiotic group, and 26 in the placebo group). From baseline to 8 weeks, probiotic supplementation resulted in a significant decrease in BDI score (17.39-9.1) compared to the placebo (18.18-15.55) and prebiotic (19.72-14.14) supplementation (p = 0.042). Inter-group comparison indicated no significant differences among the groups in terms of serum kynurenine/tryptophan ratio and tryptophan/BCAAs ratio. However, the kynurenine/tryptophan ratio decreased significantly in the probiotic group compared to the placebo group after adjusting for serum isoleucine (p = 0.048). In addition, the tryptophan/isoleucine ratio increased significantly in the probiotic group when compared to the placebo group (p = 0.023). CONCLUSION: Overall, 8 weeks of probiotic supplements to subjects with MDD resulted in an improvement in BDI score compared with placebo whereas no significant effect of prebiotic supplementation was seen. Study was registered in IRCT.ir under IRCT2015092924271N1.


Asunto(s)
Trastorno Depresivo Mayor/tratamiento farmacológico , Prebióticos/administración & dosificación , Probióticos/uso terapéutico , Adulto , Trastorno Depresivo Mayor/psicología , Método Doble Ciego , Femenino , Humanos , Masculino , Probióticos/administración & dosificación , Resultado del Tratamiento
18.
Ann Occup Environ Med ; 30: 56, 2018.
Artículo en Inglés | MEDLINE | ID: mdl-30181884

RESUMEN

BACKGROUND: Lighting is one of the environmental factors affecting the performance of the control room operators. Therefore, the aim of this study was to compare the control room operators' visual performance in two different illumination conditions at a combined cycle power plant through field-work. METHODS: Sixteen operators in day shift were evaluated with the Freiburg Visual Acuity test (FrACT) software at two lighting systems with different intensities. It includes the first phase with fluorescent illumination system (Power: 40 W, Color Temperature: 4000 Kelvin, Luminous Flux: 2780 Lumen and Model: Pars Shahab) and the second phase with a combined illumination system includes fluorescent and LED (Power: 48 W, Color Temperature: 4000 Kelvin, Luminous Flux: 5400 Lumen and Model: Mazinoor). RESULTS: Based on the results, visual performance index and visual acuity significantly increased after the intervention (p < 0.001). As to contrast, more lighting significantly reduced the percentage of recognized contrast (p < 0.001) and increased the contrast performance index (p < 0.001). CONCLUSIONS: The results of this study showed that increasing the intensity of light from the values below the allowable limit to the values above the allowable limit would increase the visual indicators in individuals.

19.
Iran J Public Health ; 47(2): 237-245, 2018 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-29445634

RESUMEN

BACKGROUND: This study estimated the prevalence of respiratory symptoms and disorders among workers exposed to exposure to volatile organic compound (VOCs) in an automobile manufacturing factory in Tehran, Iran in 2016. METHODS: Subjects of this case-control research were included 80 samples including 40 workers exposed to different level of BTEX as well as 40 unexposed individuals were considered as control group. Methods 1501 and 7602 presented by the National Institute of Occupational Safety and Health (NIOSH) were used for the sampling and analysis of compounds in the air. Gas Chromatography-Flame Ionization Detector (GC-FID) was used for analysis of compounds of interest. Six silica samples were collected during the campaign. Silica analyses were performed by using visible absorption spectrophotometry system. Lung functions were evaluated for 80 workers (40 exposed, 40 nonexposed) using spirometry system. RESULTS: The average amount of total dust and free silica measured in factory were 7.3±1.04 mg.m-3 and 0.017±0.02 mg.m-3 respectively. Average benzene, toluene, ethyl-benzene and xylene exposure levels in exposed subject's median were 0.775±0.12, 1.2±2.08, 45.8±8.5, and 42.5±23.9 ppm respectively. Statistical tests showed significant difference between pulmonary function tests (except PEF) of exposed and non-exposed individuals before and after employment (P<0.05). Workers exposed to VOCs presented lower levels of FVC, VC, and PEF than the control group except FEV1/FVC%, FEV1, FEF2575 and FEV1/VC%. CONCLUSION: Decline in lung volumes and respiratory symptoms, significant difference associated with the exposure to dust or gas, duration of exposure, and smoking habit. Therefore, lung function tests should be performed before and after the employment to identify sensitive workers candidates.

20.
Ind Health ; 56(3): 198-206, 2018 Jun 01.
Artículo en Inglés | MEDLINE | ID: mdl-29237994

RESUMEN

Electric arc welding is a routine operation in the construction of metallic structures, but the fumes generated during the welding process can threaten the health of welders. Fumes are undesirable products of the majority of welding operations and may have various detrimental effects on health. The purpose of this study was to investigate the effect of operational parameters of the shielded metal arc welding (SMAW) process on the emission of fumes. A dust monitor was used to measure the number and mass concentration of fumes generated by SMAW. Measurements were made at the distances of 23 cm (hood inlet) and 41 cm (welder's breathing zone) from the weld point, with different values assigned to three operational parameters, namely current intensity, travel speed, and heat input (HI). Number concentration (NC) decreased with the increase in particle size. The highest mass concentrations (MC) were observed for MC1 (0.35-0.5 µm) and MC8 (Larger than 6.5 µm). For reducing exposures to fumes, welders are recommended to use the lowest voltage and amperage and the highest travel speed to the extent that does not compromise in the quality of welds. For assessment of exposure to airborne particles in industrial workplaces and specially in welding operations, it is thought that taking, solely, mass concentration in to consideration and lack of attention to number concentration would not be able to reflect accurate assessment of the adverse effects of particles on the body organs.


Asunto(s)
Contaminantes Ocupacionales del Aire/análisis , Polvo/análisis , Soldadura/métodos , Humanos , Exposición Profesional/análisis , Tamaño de la Partícula , Soldadura/normas
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